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Haplin

Analyzing case-parent triad and/or case-control data with SNP haplotypes
Hakon K. Gjessing
GPL (>= 2)
Haplin performs a genetic association analysis of case-parent triad (trio) data with multiple markers. It can also incorporate complete or incomplete control triads, for instance independent control children. Estimation is based on haplotypes, for instance SNP haplotypes, even though phase is not known from the genetic data. Haplin estimates relative risk (RR + conf.int.) and p-value associated with each haplotype. It uses maximum likelihood estimation to make optimal use of data from triads with missing genotypic data, for instance if some SNPs has not been typed for some individuals. Haplin also allows estimation of effects of maternal haplotypes and parent-of-origin effects, particularly appropriate in perinatal epidemiology. Haplin allows special models, like X-inactivation, to be fitted on the X-chromosome.
Versions
Package Version Released
Haplin 5.3 1 year 26 weeks ago
Haplin 5.2 1 year 29 weeks ago
Haplin 5.0.2 1 year 35 weeks ago
Haplin 5.0.1 1 year 36 weeks ago
Haplin 5.0 1 year 41 weeks ago
Haplin 4.1 2 years 35 weeks ago
Haplin 4.0 2 years 42 weeks ago
Haplin 3.5 4 years 25 weeks ago
Haplin 3.0.2 4 years 45 weeks ago
Haplin 3.0.1
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