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Haplin

Analyzing case-parent triad and/or case-control data with SNP haplotypes
Hakon K. Gjessing
GPL (>= 2)
Haplin performs a genetic association analysis of case-parent triad (trio) data with multiple markers. It can also incorporate complete or incomplete control triads, for instance independent control children. Estimation is based on haplotypes, for instance SNP haplotypes, even though phase is not known from the genetic data. Haplin estimates relative risk (RR + conf.int.) and p-value associated with each haplotype. It uses maximum likelihood estimation to make optimal use of data from triads with missing genotypic data, for instance if some SNPs has not been typed for some individuals. Haplin also allows estimation of effects of maternal haplotypes and parent-of-origin effects, particularly appropriate in perinatal epidemiology. Haplin allows special models, like X-inactivation, to be fitted on the X-chromosome.
Versions
Package Version Released
Haplin 5.3 1 year 17 weeks ago
Haplin 5.2 1 year 20 weeks ago
Haplin 5.0.2 1 year 26 weeks ago
Haplin 5.0.1 1 year 28 weeks ago
Haplin 5.0 1 year 32 weeks ago
Haplin 4.1 2 years 27 weeks ago
Haplin 4.0 2 years 34 weeks ago
Haplin 3.5 4 years 17 weeks ago
Haplin 3.0.2 4 years 36 weeks ago
Haplin 3.0.1
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