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An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental analysis (NCA), ANOVA (lm) for a standard RT/TR 2x2x2 crossover design or a parallel study. And linear mixed effect model (lme of nlme) for a 2-treatment, 2-sequence with 2 periods or more (i.e. 2x2x3/2x2x4) replicate crossover design.