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loess compare 2 datasets [migrated]

I'm comparing matched data from a series of patients, looking at the effect of mental stress on cardiac conduction. I'm using the loess function to visually describe my data, and have 2 curves: one for with and one for without mental stress. I'd like to compare these curves.

Is it possible to compare two loess models from different (thought related) datasets. Alternatively, could I code +/- mental stress with 1/0 and use that to get a statistical relationship between the two models?

Any pointers would be super-appreciated.
Best
Malcolm